The Virtual Brain

46 EduCases for The Virtual Brain.

Learning by doing.

Simulating the human brain is the holy grail of neuroscience – offering a pioneering tool for understanding how our brain works and how to deal with its disorders like stroke, epilepsy or neurodegenerative diseases like Alzheimer’s or Parkinson’s.

While large-scale research initiatives simulate neurons and small brain regions at the cellular level on massively parallel hardware, they are still years away from clinical applications.

The Virtual Brain (TVB) takes a different approach and reduces complexity on the micro level to attain the macro organization: a TVB model of a patient's brain generates sufficiently accurate EEG, MEG, BOLD and SEEG signals by reducing the complexity millionfold through methods from statistical physics. The key is TVB’s hybrid approach of merging individual anatomy from brain imaging data with state-of-the-art mathematical modeling.

In a nutshell:
you can simulate a human brain with TVB right now, for free and with access to the source code – on average MacBooks, faculty Linux servers or supercomputers like Piz Daint in CSCS Lugano.

Since its early beginnings as network equations scribbled on a bar coaster in 2008, TVB has gained wide recognition – demonstrated by regular invitations to participate at neuroinformatics events such as INCF conferences, and workshops dedicated to High Performance Computing (HPC) (such as organized by NSG).

Today, TVB is a reference tool for full-brain simulation. TVB serves as the simulation engine in the world’s first clinical trial on predictive brain modeling in epilepsy surgery (EPINOV). TVB is also the choice of full-brain simulator in Europe’s digital research infrastructure EBRAINS and directly links to other large-scale neuroinformatics efforts such as the Allen Institute’s Mouse atlas or the Human Brain Project (HBP).

A large, growing user base of clinicians and scientists are working every day with TVB, citing its scientific groundwork in well over 100 peer-reviewed publications. Dedicated research facilities at Charité in Berlin, AMU in Marseille and Baycrest in Toronto have constructed and simulated almost 1000 individual, Connectome-based brain network models and published their findings, clocking in upwards of 10 million CPU core hours.

Past events

New developments

  • 6th TVB-EBRAINS Integrated Workflows Workshop

    June 9

    TVB-EBRAINS Integrated Workflows - 6th Virtual Workshop will be held on September 3rd from 1200 to 1500 CEST.

    The purpose of this Workshop Series is to discuss existing interfaces and workflows of TVB in ERRAINS that have been developed in SGA2 and those under development or being planned for SGA3.

    The agenda is still forthcoming, however amongst other topics, we will discuss the [BIDS

  • European Institute for Theoretical Neuroscience (EITN) Workshop

    June 9

    Learn about TVB-integrated workflows in upcoming European Institute for Theoretical Neuroscience (EITN) workshop Computational Neuroscience in EBRAINS on June 10th.

    Register [here](

  • TVB-Fac-Hub

    EBRAINS TVB Facility Hub

    June 8

    The Virtual Brain Facility Hub at Aix-Marseille University will provide expert support for activities linked to the use of The Virtual Brain. The Hub aims to increase the capacity of neuroscientists to use ICT tools, such as TVB and EBRAINS, in order to advance scientific knowledge and facilitate the translation of research into clinical applications. To find out more, [Click Here](

  • TVB-EBRAINS Integrated Workflows - 5th Virtual Workshop

    May 29

    TVB-EBRAINS Integrated Workflows - 5th Virtual Workshop will be held on June 4th, 1300 to 1500 CET.

    The purpose of this Workshop Series is to discuss existing interfaces and workflows of TVB in ERRAINS that have been developed in SGA2 and those under development or being planned forSGA3.

    More info [here](

  • TVB v2 blog illustration

    BIG new release: The Virtual Brain version 2.2

    April 1

    Our scientists and developers are very proud to announce the next generation of The Virtual Brain: version 2.2! Many core parts of the software have been rewritten to make it faster, cleaner, shorter, much more powerful and just overall nicer!

    First thing: upgrade existing installations from v1.5.8

    TVB 2.2 has a new storage architecture underneath. Your data will be migrated automatic

  • McGill Summer School: The Virtual Brain lecture and workshop

    March 23

    Learn to use The Virtual Brain: Lectures with subsequent hands on session at the McGill Summer School in Nonlinear Dynamics for the Life Sciences with Applications to Neuroscience and Psychology.

    Registration is open!

    Find out more here

  • Brain Modeling Service image

    TVB-EBRAINS Integrated Workflows - 4th Virtual Workshop

    March 1

    TVB-EBRAINS Integrated Workflows - 4th Virtual Workshop will be held on March 12th at 9am to 15:00 CET.

    The purpose of this workshop series is to discuss interfaces and workflows of The Virtual Brain (TVB) in the EU Flagship’s Research Infrastructure EBRAINS.

    Registration is now closed.

  • BIDS Extension Proposal: Computational Model Specifications - Contributions Welcome!

    February 16

    Brain Imaging Data Structure [BIDS] is a community effort to define standards in data / metadata. Please contribute to this proposal which extends the original specification to further integrate different kinds of data, such as imaging methods we use for brain visualisation and simulation.

    You can find the draft document here, and all are welcome to add suggestions to this draft: [BIDS extensi