The Virtual Brain

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EduCases for The Virtual Brain.

Learning by doing.

  • LEARN: TVB Clinical Applications - Stroke Recovery & Dementia

    • Stroke

    This lecture presents two recent clinical case studies using TVB: stroke recovery and dementia (due to Alzheimer’s Disease (AD)).

    Using a multi-scale neurophysiological model based on empirical multi-modal neuroimaging data, we show how local and global biophysical parameters characterize changes in  individualized patient-specific brain dynamics, predict recovery of motor function for stroke patients, and correlate with individual differences in cognition for AD patients.

    Topics covered in this lesson by Randy McIntosh

    • General introduction to stroke
    • TVB simulation workflow for stroke patients
    • Structural reconstruction: “Virtual Brain Transplant”
    • Parameter space exploration and fitting
    • General introduction to dementia
    • TVB simulation workflow for patients with dementia
    • Pre-processing issues related to atrophy
    • Two-stage modeling: sub- and full-brain network model
    • Cognition predictor: model parameters vs. metrics of neuroimaging data